Flaxilip

Capsules

 

Herbal Supplement for Balancing the Cholesterol Levels

 

 

Flaxilip is a perfectly blended formulation containing Allium Sativum, Commiphora Mukul, Linum Usitatissimum and Trigonella Foenum-graecum which helps in managing the cholesterol levels in the body by naturally and safely improving cholesterol synthesis and thereby regulating lipid metabolism

 

 


Composition: Eachcapsule contains:

 

Dehydrated Allium Sativum powder                 200mg

(Standardized for Allicin1%)

                                                                                       

Commiphora Mukul (Guggulu) Extract               100mg

(Standardized for Guggallsterone E&Z2.5%)

 

Linum Usitatissimum Oil B.P.                           700 mg

(Flaxseed Oil B.P.)

 

Trigonella Foenum-graecum Extract                 10mg

(Standardized for 10% Saponincontent)

 

Excipients                                                     q.s.

 

Uses: According to the age-old scriptures of Ayurveda and other complementary and alternative systems, the herbal ingredients of this product are claimed to be useful in managing abnormally high cholesterol levels

 

Dosage: One capsule two times daily or as directed by physician

 

Contraindications: Not reported in recommended dosage

 

Side Effects: Not reported in the recommended dosage

 

Presentation: HDPE pack of 60capsules

 

Storage: Store in a cool dry place. Ensure that container lid is tightly closed.

 

Price:  $49.95

 

 

 

Research References: (Primary Ingredients)

 

Methika (Trigonella foenum-graecum Linn.)

 

Al-Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med. J 2002; Nov, 23(11);1327-1331.

 

Brasch E, Ulbricht C, Kuo G, et al. Therapeutic applications of fenugreek. Altern Med Rev 2003; Feb, 8(1):20-27.

 

Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of Fenugreek in non-insulin dependent diabetics. Eur J Clin Nutr, 1988; 42:51-54.

 

Raju J, Gupta D, Rao AR, Yadava PK, Baquer NZ, Trigonella foenum-graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem. 2001 Aug;224(1-2):45-51.

 

Ribes G et al. Hypocholesterolaemic and hypotriglyceridaemic effects of subfractions from fenugreek seeds in alloxan diabetic dogs. Phytother Res. 1987; 1:38-42.

 

Shani J et al. Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (Leguminosae) seeds and their major alkaloids in alloxan diabetic and normal rats. Arch Int Pharmacodyn Ther 1974;210:27-37.

 

Sharma RD, Sarkar DK, Hazra B, et al. Hypolipidaemic effect of fenugreek seeds: a chronic study in non-insulin dependent patients. Phytother Res 1996;10:332-334.

 

Sharma RD. An evaluation of hypocholesterolemic factor of fenugreek seeds (T. foenum graecum) in rats. Nutr Rep Int 1986; 33:669-677.

 

Sur P, Das M, Gomes A, Vedasiromoni JR, Sahu NP, Banerjee S, Sharma RM, Ganguly DK. Trigonella foenum-graecum (fenugreek) seed extract as an antineoplastic agent. Phytother Res. 2001 May; 15(3): 257-9.

 

 

 

Guggulu:

 

Agarwal RC, Singh SP, Saran RK, Das SK, Sinha N, Asthana OP, Gupta PP, Nityanand S, Dhawan BN, and Agarwal SS. Clinical trial of gugulipid – a new hyperlipidemic agent of plant origin in primary  hyperlipidema. Indian J. Med. Res., 84:626, 1986.

 

Dixit VP, Joshi S, Sinha R, Bhargava SK and Varma M. Hyperlipidemic activity of guggal resin (Commiphora mukul) and garlic (Allium sativum Linn.) in dogs (Canis familaris) and monkeys (Presbytis entellus entellus Dufresne). Biochem. Exp. Biol. 16(4):421, 1980.

 

Kuppurajan K, Rajagopalan SS, Rao TK and Sitaraman R. Effect of guggulu (Commiphora mukul Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. J. Assoc. Phys. India., (26):367, 1978.

 

Nityanand S and Kapoor NK. Cholesterol lowering activity of the various fractions of the guggal. Indian J. Exp. Biol., 11:395, 1973.

 Satyavati GV. Gum guggul (Commiphora mukul)—The success story of an ancient insight leading to a modern discovery. Indian J. Med. Res., 87:237, 1988.

 

Sharma K, Puri AS, Sharma R and Prakash S. Effect of gum guggul on serum lipids in obese subjects. J. Res. Indian Med., Yoga and Homoeo., 11(2):132, 1976.

 Sidhu LS, Sharma K, Puti AS and Prakash S. Effect of gum guggul on body weight and subcutaneous tissue folds. J. Res. Indian Med. Yoga, Homoeo., 11(2):16, 1976.

 

Singh RB, Niaz MA and Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovascular Drugs Ther., 8(4):659, 1994.

 Wu J, Xia C, Meier J, Li S, Hu X, Lala DS. The hyperlipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol, 16(7):1590-7, 2000.

 

 

 

Garlic

 

Lawson LD et al. HPLC analysis of allicin and other thiosulfinates in garlic clovehomogenates. Planta medica, 1991, 57:263-270.

 

Auer W, Eiber A, Hertkorn E, Hypertension and hyperlipidemia: garlic helps in mild cases. British Journal of Clinical Practice, 1990, 44:3-6.

 

Kiesewetter H, et al. Effects of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. European Journal of Clinical Pharmacology, 1993, 45:333-336.

 

Kiesewetter H, et al. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. International journal of clinical pharmacology, therapy and toxicology, 1991, 29:151-155.

 

Sharma VD, et al. Antibacterial property of Allium sativum. In vivo and in vitro studies. Indian Journal of Experimental Biology, 1980, 15:466-469.

 

Moore GS, Atkins RD. The antifungistatic effects of an aqueous garlic extract on medically important yeast-like fungi. Mycologia, 1977, 69:341-345.

 

Caporaso N, Smith SM, Eng RHK, Antifungal activity in human urine and serum after ingestation of garlic (Allium sativum). Antimicrobial agents and chemotherapy, 1983, 5:700-702.

 

Farbman et al. Antibacterial activity of garlic and onions: a historical perspective. Pediatrics infectious disease journal, 1993, 12:613-614.

 

Lawson LD, Hughes BG. Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial products. Thrombosis Research, 1992, 65:141-156.

 

Mader FH. Treatment of hyperlipidema with garlic powder tablets. Evidence from the German Association of General Practitioner's multicentric placebo-controlled, double blind study. Arzneimittel-Forschung, 1990, 40:1111-1116.

 

Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids, 1993, 28:613-619.

 

Gebhardt R., Beck H, Wagner KG. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochimica biophysica acta, 1994, 1213:57-62.

 

 Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and tricylglycerol synthesis. Lipids, 1994, 29:189-193.

 

Mand JK, et al. Role of Garlic (Allium sativum) in the reversal of atherosclerosis in rabbits. In: Proceedings of the Third Congress of the Federation of Asian and Oceanian Biochemist. Bangkok, 1983:79.

 

Lata S, et al. Beneficial effects of Allium sativum, Allium cepa and Commiphora mukul on experimental hyperlipidemia and atherosclerosis: a comparative evaluation. Journal of post graduate medicine., 1991, 37:132-135.

 

 Ogawa H et al., Effect of garlic powder on lipid metabolism in stroke-prone spontaneously hypertensive rats. Nippon eiyo, shokuryo gakkaishi, 1993, 46:417-423.

 

Foushee DB, Ruffin J, Banerjee U. Garlic as a natural agent for the treatment of hypertension: A preliminary report. Cytobios, 1982:145-152.

 

Das I, Khan NS, Sooranna SR. Nitric oxide synthetase activation is a unique mechanism of garlic action. Biochemical Society Transactions. 1995, 23:S136.

 

Das I, Khan NS, Sooranna SR. Potent activation of nitric oxide synthetase by garlic: a basis for it's therapeutic applications. Current medical research opinions, 1995, 13:257-263.

 

Mohammad SM, Woodward SC. Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (garlic). Thrombosis research., 1986, 44:793-806.

 

Jain RC, Konat DB. Blood sugar lowering activity of garlic (Allium sativum Linn.). Medikon, 1977, 6:12-18.

 

Aqel MB, Gharaibah MN, Salhab AS. Direct relaxant effects of garlic juice on smooth and cardiac muscles. Journal of ethnopharmacology, 1991, 33:13-19.

 

Harenberg J, Giese C, Zimmerman R. Effects of dried garlic on blood coagulation, fibrinolysis, platelet aggregation, and serum cholesterol levels in patients with hyperlipoproteinemia. Atherosclerosis, 1988, 74:247-249.

 

Zhang YS, Chen XR, Yu YN. Antimutagenic effect of garlic (Allium sativum) on 4NQO-induced mutagensis in Escherichia coli WP2. Mutation research, 1989, 227:215-219.

 

 

Flaxseed Oil

 

Clark WF, Kortas C, Heidenheim AP, Garland J, Spanner E, Parbtani A. Flaxseed in lupus nephritis: a two-year non-placebo-controlled crossover study. J Am Coll Nutr. 2001;20(2 Suppl):143-148.

 

De Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994;343:1454-1459.

 

Deutch B. Menstrual pain in Danish women correlated with low n-3 polyunsaturated fatty acid intake. Eur J Clin Nutr. 1995;49(7):508-516.

 

Edwards R, Peet M, Shay J, Horrobin D. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord. 1998;48:149-155.

 

Frieri G, Pimpo MT, Palombieri A, et al. Polyunsaturated fatty acid dietary supplementation: an adjuvant approach to treatment of Helicobacter pylori infection. Nutr Res. 2000;20(7):907-916.

 

Harper CR, Jacobson TA. The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease. Arch Intern Med. 2001;161(18):2185-2192.

 

Hibbeln JR, Salem N, Jr. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr. 1995;62(1):1-9.

 

Horrobin DF. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophrenia Res. 1998;30(3):193-208.

 

Horrobin DF, Bennett CN. Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis. Prostaglandins Leukot Essent Fatty Acids. 1999;60(4):217-234.

 

Jeschke MC, Herndon DN, Ebener C, Barrow RE, Jauch KW. Nutritional intervention high in vitamins, protein, amino acids, and omega-3 fatty acids improves protein metabolism during the hypermetabolic state after thermal injury. Arch Surg. 2001;136:1301-1306.

 

Lockwood K. Moesgaard S, Hanioka T, Folkers K. Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids, and coenzyme Q10. Mol Aspects Med. 1994;15Suppl:s231-s240.

 

Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risks. Prostate. 2001;47(4):262-268.

 

Okamoto M, Misunobu F, Ashida K, et al. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. Int Arch Allergy Immunol. 2000;122(2):137-142.

 

Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women thru diet and lifestyle. N England J Med. 2000;343(1):16-22.

 

Talom RT, Judd SA, McIntosh DD, et al. High flaxseed (linseed) diet restores endothelial function in the mesenteric arterial bed of spontaneously hypertensive rats. Life Sci. 1999;16:1415-1425.

 

Terry P, Lichtenstein P, Feychting M, Ahlbom A, Wolk A. Fatty fish consumption and risk of prostate cancer. Lancet. 2001;357(9270):1764-1766.

 

Zambon D, Sabate J, Munoz S, et al. Substituting walnuts for monosaturated fat improves the serum lipid profile of hypercholesterolemic men and women. Ann Intern Med. 2000;132:538-546.