Contudol

Capsules

 

Herbal Supplement for Joint Pains and Swellings

 

 

A combination of 4 herbs Boswellia serrata, Curcuma longa, Moringa oleifera and Zingiber officinalis is a natural herbal dietary supplement useful in the management of arthritis and other musculosketetal disorders where it helps to reduce pain and improve mobility

 

Composition: Each capsule contains:

 
 

Boswellia Serrata Extract 200 mg

(Standardized for Boswellic acid 60%)

 

Curcuma Longa Extract 100 mg

(Standardized for Curcuminoids 20%)

 

Moringa Oleifera Extract 50 mg

(Standardized for Tannins 1%)

 

Zingiber Officinale Extract 35 mg

(Standardized for Gingerol 5%)

 

Excipients q.s.

 

Uses: According to the age-old scriptures of Ayurveda and other complementary and alternative systems, the herbal ingredients of this product are claimed to be useful in joint pains in different arthritic conditions, pain associated with cervical and lumbar spondylosis, sciatica, sprains, frozen shoulder and other painful inflammatory conditions

 

Dosage: Two capsules two times a day or as directed by the physician

 

Contraindications: No specific contraindications except hypersensitivity and during pregnancy and lactation

 

Side Effects: No side effects reported when used as directed

 

Presentation: HDPE pack of 60 capsules

 

Storage: Store in a cool dry place protected from light

 

 Price:  $39.95

 

 

 

Research References: (Primary Ingredients)

 

  

Boswellia:

 

Ammon HPT., Safayhi H., Mack T. and Sabieraj J. Mechanism of anti-inflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol., 38(2-3):113, 1993.

 

Atal CK., Singh GB., Batra S., Sharma S., and Gupta OP. Salai guggul ex-Boswella serrata a promising antihyperlipidemic and antiarthritic agent. Ind. J. Pharm., 12:59, 1980.

 

Etzel R. Special extract of Boswellia serrata (H15) in the treatment of rheumatoid arthritis. Phytomedicine, 3:91, 1996.

 

Ghoshal S, Mukhopadhyay MJ, Mukherjee A. Clastogenic effects of dietary supplement Spirulina alga, and some medicinal plant products from Boswellia serrata, Withania somnifera on mice. Indian J. Eperiment. Biol., 39(10):1068-70, 2001.

 

Glaser T., Winter S., Groscurth P., Safayhi H., Sailer ER., Ammon HPT., Schabet M. and Weller M. Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity. Br J. Cancer, 80(5-6):756, 1999.

 

Gupta I., Parihar A., Malhotra P., Singh GB., Ludtke T., Safayhi H. and Ammon HPT. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur. J. Med. Res., 2(1):37, 1997.

 

Gupta I., Gupta V., Parihar A., Gupta S., Ludtke R., Safayhi H., Ammon HPT. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur. J. Med. Res., 17:3(11):511, 1998.

 

Gupta I, Parihar A., Malhotra P., Gupta S., Ludtke R., Safayhi H., Ammon HP. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med., 67(5):391-5, 2001.

 

Huang MT., Badmaev V., Ding Y., Liu Y., Xie JG. And Ho CT. Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Biofactors, 13(1-4):225, 2000.

 

Jing Y., Nakajo S., Xia L., Nakaya K., Fang Q., Waxman S., and Han R. Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. Leuk. Res., 23(1):43, 1999.

 

Kar A., Effect of the gum resin of Boswellia serrata on the cardiovascular system and isoloated tissues. Ind. Drug and Pharm. Ind., 12(4):17-20, 1977.

 

Knaus U., and Wagner H. Effects of Boswellic acid of Boswellia serrata and other triterpenic acids on the complement system. Phytomedicine, 3:77, 1996.

 

 

Curcuma Longa:

 

Ammon HPT., Safayhi H., Mack T. and Sabieraj J. Mechanism of anti-inflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol., 38(2-3):113, 1993.

 

Apisariyakul A. Vanittanakom N, Buddhasukh D. Antifungal activity of tumeric oil extracted from Curcuma longa (Zingiberaceae). J. Ethnopharmacol., 49:163, 1995.

 

Arora RB, Basu N, Kapoor N, Jain AP. Anti-imflammatory studies on Curcuma longa (tumeric). Ind. J. Med. Res., 59:1289, 1971.

 

Basu AP. Antibacterial activity of Curcuma longa. Indian J. Pharm., 33:131, 1971.

 

Brouet I and Ohshima H. Curcumin, an anti-tumor promotor and anti-imflammatory agent, inhibits induction of nitric oxide synthetase in activated macrophages. Biochem. Biophys. Res., Commun., 206:533, 1995.

 

Chandra D and Gupta S. Anti-imflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi). Ind. J. Med. Res., 60:138, 1972.

 

Dikshit M, Rastogi L, Shukla R, Srimal RC. Prevention of ischaemia-induced biochemical changes by curcumin and quinidine in the cat heart. Indian J. Med. Res., 101:31, 1995.

 

Kunchandy E and Rao MNA. Oxygen radical scavenging activity of curcumin. Int. J. Pharmaceutics, 58:237, 1990.

 

Kuttan R, Sudheeran PC, Joshi CD. Tumeric and curcumin as topical agents in cancer therapy. Tumori, 28.73(1):29, 1987.

 

Osawa T, Sugiyama Y, Inayoshi M, et al. Antioxidative activity of tetrahydrocurcuminoids. Biosci. Biotechnol. Biochem., 59(9):1609, 1995.

 

Reddy S, and Aggarwal BB. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett., 341(1):19, 1994.

 

 Sikora E, Bielak-Zmijewska A, Piwocka K, et al. Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment. Biochem. Pharm., 54(8):899, 1997.

 

Sreejayan and Rao MNA. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol., 46(12):1013, 1994.

 Srinivas L, Shalina VK, Shylaia M. Tumerin, a water soluble antioxidant peptide from tumeric (Curcuma longa). Arch. Biochem. Biophys., 292(2):617, 1992.

 

Stoner GD and Muktar H. Polyphenols as cancer chemopreventive agents. J. Cell Biochem. Suppl. 22:169, 1995.